A transcriptomic analysis of the phylum Nematoda.
Identifieur interne : 002C00 ( Main/Exploration ); précédent : 002B99; suivant : 002C01A transcriptomic analysis of the phylum Nematoda.
Auteurs : John Parkinson [Canada] ; Makedonka Mitreva ; Claire Whitton ; Marian Thomson ; Jennifer Daub ; John Martin ; Ralf Schmid ; Neil Hall ; Bart Barrell ; Robert H. Waterston ; James P. Mccarter ; Mark L. BlaxterSource :
- Nature genetics [ 1061-4036 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Base Sequence, Chromosome Mapping, Computational Biology, Conserved Sequence (genetics), Databases, Genetic, Evolution, Molecular, Expressed Sequence Tags, Genetic Variation, Genome, Molecular Sequence Data, Nematoda (genetics), Phylogeny, Protein Structure, Tertiary (genetics), Sequence Analysis, DNA, Species Specificity.
- MESH :
- genetics : Conserved Sequence, Nematoda, Protein Structure, Tertiary.
- Animals, Base Sequence, Chromosome Mapping, Computational Biology, Databases, Genetic, Evolution, Molecular, Expressed Sequence Tags, Genetic Variation, Genome, Molecular Sequence Data, Phylogeny, Sequence Analysis, DNA, Species Specificity.
Abstract
The phylum Nematoda occupies a huge range of ecological niches, from free-living microbivores to human parasites. We analyzed the genomic biology of the phylum using 265,494 expressed-sequence tag sequences, corresponding to 93,645 putative genes, from 30 species, including 28 parasites. From 35% to 70% of each species' genes had significant similarity to proteins from the model nematode Caenorhabditis elegans. More than half of the putative genes were unique to the phylum, and 23% were unique to the species from which they were derived. We have not yet come close to exhausting the genomic diversity of the phylum. We identified more than 2,600 different known protein domains, some of which had differential abundances between major taxonomic groups of nematodes. We also defined 4,228 nematode-specific protein families from nematode-restricted genes: this class of genes probably underpins species- and higher-level taxonomic disparity. Nematode-specific families are particularly interesting as drug and vaccine targets.
DOI: 10.1038/ng1472
PubMed: 15543149
Affiliations:
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Le document en format XML
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We analyzed the genomic biology of the phylum using 265,494 expressed-sequence tag sequences, corresponding to 93,645 putative genes, from 30 species, including 28 parasites. From 35% to 70% of each species' genes had significant similarity to proteins from the model nematode Caenorhabditis elegans. More than half of the putative genes were unique to the phylum, and 23% were unique to the species from which they were derived. We have not yet come close to exhausting the genomic diversity of the phylum. We identified more than 2,600 different known protein domains, some of which had differential abundances between major taxonomic groups of nematodes. We also defined 4,228 nematode-specific protein families from nematode-restricted genes: this class of genes probably underpins species- and higher-level taxonomic disparity. Nematode-specific families are particularly interesting as drug and vaccine targets.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Barrell, Bart" sort="Barrell, Bart" uniqKey="Barrell B" first="Bart" last="Barrell">Bart Barrell</name><name sortKey="Blaxter, Mark L" sort="Blaxter, Mark L" uniqKey="Blaxter M" first="Mark L" last="Blaxter">Mark L. Blaxter</name><name sortKey="Daub, Jennifer" sort="Daub, Jennifer" uniqKey="Daub J" first="Jennifer" last="Daub">Jennifer Daub</name><name sortKey="Hall, Neil" sort="Hall, Neil" uniqKey="Hall N" first="Neil" last="Hall">Neil Hall</name><name sortKey="Martin, John" sort="Martin, John" uniqKey="Martin J" first="John" last="Martin">John Martin</name><name sortKey="Mccarter, James P" sort="Mccarter, James P" uniqKey="Mccarter J" first="James P" last="Mccarter">James P. Mccarter</name><name sortKey="Mitreva, Makedonka" sort="Mitreva, Makedonka" uniqKey="Mitreva M" first="Makedonka" last="Mitreva">Makedonka Mitreva</name><name sortKey="Schmid, Ralf" sort="Schmid, Ralf" uniqKey="Schmid R" first="Ralf" last="Schmid">Ralf Schmid</name><name sortKey="Thomson, Marian" sort="Thomson, Marian" uniqKey="Thomson M" first="Marian" last="Thomson">Marian Thomson</name><name sortKey="Waterston, Robert H" sort="Waterston, Robert H" uniqKey="Waterston R" first="Robert H" last="Waterston">Robert H. Waterston</name><name sortKey="Whitton, Claire" sort="Whitton, Claire" uniqKey="Whitton C" first="Claire" last="Whitton">Claire Whitton</name></noCountry><country name="Canada"><noRegion><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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